Evaluating the Cardiovascular Safety of Nonsteroidal Anti-Inflammatory Drugs
نویسندگان
چکیده
منابع مشابه
Nonsteroidal anti-Inflammatory drugs and cardiovascular risk.
Nonsteroidal anti-inflammatory drugs (NSAID) inhibit cyclooxygenase (COX) enzymes, which exist in at least two isoforms, COX-1 and COX-2. Aspirin and older agents in this class are nonselective inhibitors of both COX-1 and COX-2. Newer agents termed "coxibs" are selective inhibitors of COX-2. Among the NSAID, only aspirin has been proven to significantly reduce cardiovascular risk, primarily th...
متن کاملNonsteroidal Anti-Inflammatory Drugs and Cardiovascular Risk
electivity toward cyclooxygenase (COX)-2 is usually dened by comparing the capacity of individual nonsteroidal nti-inflammatory drugs (NSAIDs) to inhibit in vitro or ex ivo the generation of thromboxane A2 (TXA2) through OX-1 in aggregating platelets with the capacity to inhibit rostaglandin (PG) E2 generation through COX-2, exressed in leukocytes after an inflammatory stimulus (1). his rather ...
متن کاملNonsteroidal anti-inflammatory drugs.
Non-steroidal anti-inflammatory drugs (NSAIDs) are usually defined as those agents that inhibit one or more reactions involved in the production of prostaglandins and thromboxanes, important mediators of the inflammatory process in many organs and tissues. They find use in horses in the supportive treatment of a variety of systemic states and painful musculoskeletal or soft tissue conditions. T...
متن کاملGastrointestinal and cardiovascular risks of nonsteroidal anti-inflammatory drugs.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed but can have serious gastrointestinal (GI) and cardiovascular side effects, which have led to the withdrawal of some of these drugs and continuing uncertainty about the best approach to patients requiring NSAID therapy, particularly in those with GI or cardiovascular risk factors. To define the risks to the GI and cardiovascula...
متن کامل[Nonsteroidal anti-inflammatory drugs: cardiovascular, cerebrovascular and renal effects].
The nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most often prescribed drugs in the world. This heterogeneous class of drugs includes aspirin and several other selective or non-selective cyclooxygenase (COX) inhibitors. The non-selective NSAIDs are the oldest ones and are called traditional or conventional NSAIDs. The selective NSAIDs are called COX-2 inhibitors. In recent years,...
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ژورنال
عنوان ژورنال: Circulation
سال: 2017
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.117.027288